Grandaxin (Tofisopam)

Grandaxin is a daytime tranquilizer.

Indications:

• neuroses and neurosis-like states ( emotional stress , autonomic disorders , moderate anxiety, apathy, decreased activity , intrusive experiences );
• reactive depression with moderately severe psychopathology ;
• mental adaptation disorder ( PTSD );
• menopausal syndrome ( as a standalone tool , as well as in combination with hormonal therapy );
• premenstrual syndrome ;
• cardialgiae (alone or in combination with other drugs );
• alcohol withdrawal syndrome ;
• myasthenia gravis, myopathy , neurogenic muscular atrophy and other pathological conditions with secondary neurotic symptoms when anxiolytics contraindicated with severe muscle relaxant effect.

Contraindications:

• Hypersensitivity to the active or any other component of the drug or any other benzodiazepines ;
• state, accompanied by severe psychomotor agitation , aggression or severe depression ;
• decompensated respiratory failure ;
• I trimester of pregnancy;
• lactation ;
• sleep apnea syndrome( in history);
• simultaneous application of tacrolimus , sirolimus , cyclosporine ;
• galactose intolerance , congenital lactase deficiency or malabsorption of glucose and galactose ( product contains lactose monohydrate) .

Precautions:

decompensated chronic respiratory distress , acute respiratory failure in history, angle-closure glaucoma , epilepsy , organic brain lesions ( eg, atherosclerosis ) .

Pregnancy and breast-feeding:

Contraindicated in I trimester of pregnancy. At the time of treatment should stop breastfeeding.

Side effects:

GI : loss of appetite , constipation, increased separation of gas , nausea , dry mouth . In some cases, possible congestive jaundice .
CNS: may experience headache, insomnia, irritability , agitation , confusion, seizures may occur in patients with epilepsy .
Allergic reactions: rash, scarlatiniform rash, itching.
Musculoskeletal system : muscle tension, muscle pain.
Respiratory system : respiratory depression .

Dosage and administration:

The dosage set individually according to the patient, the clinical form of the disease and individual sensitivity to the drug. Adults appoint 50-100 mg (1-2 tabs). 1-3 times a day. Of irregular use can take 1-2 tablets. The maximum daily dose - 300 mg.
Elderly patients and patients with renal insufficiency: the daily dose is reduced approximately 2-fold.