Fluoxetine

Fluoxetine is an antidepressant, also known as "Happy pills"
Name in Cyrillic : Флуоксетин

Indications:

• Depression (especially accompanied by fear), including when other antidepressants are ineffective
• obsessive-compulsive disorders
• bulimia nervosa

Contraindications

Hypersensitivity, the use of MAO inhibitors (in the previous 2 weeks), hepatic and renal insufficiency (creatinine clearance less than 10 ml / min), epilepsy and convulsive conditions (in the anamnesis), suicidal mood, diabetes mellitus, atony of the bladder, angle-closure glaucoma, hypertrophy of the prostate.

Interaction

Fluoxetine is incompatible with MAO inhibitors, other antidepressants, furazolidone, procarbazine, as it causes serotonergic syndrome (chills, hyperthermia, muscle rigidity, myoclonus, vegetative lability, hypertensive crisis, agitation, tremor, motor anxiety, convulsions, diarrhea, hypomanic state, delirium, coma , a fatal outcome is possible.
With simultaneous administration of Fluoxetine with drugs that have a high degree of binding to plasma proteins (oral anticoagulants, oral hypoglycemic agents, cardiac glycosides, etc.)- it's possible to mutually displace from the bond with the protein with a change in the concentration of free fraction in the blood, the risk of side effects increases. The risk of bleeding increases when taking warfarin. Fluoxetine inhibits the biotransformation of drugs metabolized with the participation of the cytochrome P450 isoenzyme CYP2D6 (tricyclic antidepressants, dextromethorphan, etc.). Fluoxetine lengthens T1/2 of Diazepam, potentiates the effects of Alprazolam. With simultaneous administration Fluoxetine changes (increases or decreases) the concentration of lithium in blood plasma, increases the content of phenytoin (before the clinical manifestations of its overdose); The level of tricyclic antidepressants (imipramine, desipramine) increases 2-10 times. Tryptophan enhances the serotonergic properties of Fluoxetine (agitation, motor anxiety, and gastrointestinal dysfunction are possible).
Fluoxetine is incompatible with ethanol.

Dosage:

The initial dose is 20 mg 1 time per day in the morning
If necessary- the dose may be increased after 3-4 weeks to 2-3 times per day
The maximum daily dose for adults is 80 mg.

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