Trileptal® Active substance : Oxcarbazepine )
Dosing and AdministrationOxcarbazepine pills should be taken regardless of meal (during, after meals or in between meals).
Trileptal® can be used as a monotherapy, or in combination with other antiepileptic drugs. In both cases, the course of treatment begins with a clinically effective dose, the frequency of administration is 2 times a day. The dose may be increased depending on the response to therapy. When replacing another antiepileptic drug with Trileptal® - the dose of the drug should be gradually reduced at the start. When Trileptal ® is used as part of combination therapy - a reduction in the dose of concomitant antiepileptic drugs and / or a slower increase in the dose of Trileptal® may be required.
Adults and elderly patientsMonotherapy: the initial dose is 600 mg / day (8-10 mg / kg / day), divided into 2 doses. A good therapeutic response was observed in the dose range of 600-2400 mg / day, with the majority of patients having a good clinical effect at a dose of 900 mg / day. If necessary, a gradual increase in the dose is possible. The dose is increased by no more than 600 mg / day, with an interval of about 1 week, until the desired therapeutic response is achieved.
In patients who had not previously received antiepileptic drugs, the effective dose was 1200 mg / day, in patients who had previously received but did not respond well to therapy with other antiepileptic drugs - 2,400 mg / day.
Combination therapy: the initial dose is 600 mg / day (8-10 mg / kg / day), divided into 2 doses. A good therapeutic response was observed in the dose range of 600-2400 mg / day. If necessary, a gradual increase in the dose is possible. The dose is increased by no more than 600 mg / day, with an interval of about 1 week, until the desired therapeutic response is achieved.
ChildrenMonotherapy and combination therapy: the recommended initial dose is 8-10 mg / kg / day for 2 divided doses.
If necessary, to achieve the desired therapeutic effect, it is possible to gradually increase the dose: at intervals of about 1 week, the dose is increased by a maximum of 10 mg / kg / day, to a maximum daily dose of 60 mg / kg.
Oxcarbazepine is intended for use in children from 1 month and older. The use of the drug in children under 1 month in controlled clinical trials has not been studied.
With the use of Oxcarbazepine - when corrected for body weight, the apparent clearance in children is significantly reduced with age. Children aged 1 month to 4 years may require a dose of the drug 2 times the dose for adults, when adjusted for body weight; Children between the ages of 4 and 12 may require a dose that exceeds the adult dose by 50% when adjusted for body weight. The use of Oxcarbazepine in a daily dose of 2,400 mg as part of combination therapy without reducing the dose of another antiepileptic drug was accompanied by poor tolerance in most patients, mainly due to the development of adverse events from the nervous system. The use of Oxcarbazepine in a daily dose of more than 2,400 mg has not been studied.
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