Grandaxin (Tofisopam)

Grandaxin is a daytime tranquilizer.


  • neuroses and neurosis-like states ( emotional stress , autonomic disorders , moderate anxiety, apathy, decreased activity , intrusive experiences );
  • reactive depression with moderately severe psychopathology ;
  • mental adaptation disorder ( PTSD );
  • menopausal syndrome ( as a standalone tool , as well as in combination with hormonal therapy );
  • premenstrual syndrome ;
  • cardialgiae (alone or in combination with other drugs );
  • alcohol withdrawal syndrome ;
  • myasthenia gravis, myopathy , neurogenic muscular atrophy and other pathological conditions with secondary neurotic symptoms when anxiolytics contraindicated with severe muscle relaxant effect.


  • Hypersensitivity to the active or any other component of the drug or any other benzodiazepines ;
  • state, accompanied by severe psychomotor agitation , aggression or severe depression ;
  • decompensated respiratory failure ;
  • I trimester of pregnancy;
  • lactation ;
  • sleep apnea syndrome( in history);
  • simultaneous application of tacrolimus , sirolimus , cyclosporine ;
  • galactose intolerance , congenital lactase deficiency or malabsorption of glucose and galactose ( product contains lactose monohydrate) .


decompensated chronic respiratory distress , acute respiratory failure in history, angle-closure glaucoma , epilepsy , organic brain lesions ( eg, atherosclerosis ) .

Pregnancy and breast-feeding:

Contraindicated in I trimester of pregnancy. At the time of treatment should stop breastfeeding.

Side effects:

GI : loss of appetite , constipation, increased separation of gas , nausea , dry mouth . In some cases, possible congestive jaundice .
CNS: may experience headache, insomnia, irritability , agitation , confusion, seizures may occur in patients with epilepsy .
Allergic reactions: rash, scarlatiniform rash, itching.
Musculoskeletal system : muscle tension, muscle pain.
Respiratory system : respiratory depression .

Dosage and administration:

The dosage set individually according to the patient, the clinical form of the disease and individual sensitivity to the drug. Adults appoint 50-100 mg (1-2 tabs). 1-3 times a day. Of irregular use can take 1-2 tablets. The maximum daily dose - 300 mg.
Elderly patients and patients with renal insufficiency: the daily dose is reduced approximately 2-fold.

!! please take a note, that product may be labeled in Russian and provided with instructions in Russian. if you need instructions in English - you can download PDF file below

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Grandaxin® (Tofisopam)


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