Active substance : pregabalin

Indications for use:

epilepsy, neuropathic pain, postherpetic neuralgia, diabetic peripheral neuropathy ,fibromyalgia, anxiety disorders.

Usual Adult Dose for Diabetic Neuropathy

Initial dose: 50 mg 3 times a day

The maximum recommended dose of Pregabalin is 100 mg 3 times a day in patients with a creatinine clearance of at least 60 mL/min.

The dose may be increased to 100 mg 3 times a day within 1 week based on efficacy and tolerability.

!! please take a note, that product can be labeled in Russian and provided with instructions in Russian. if you need instructions in English - please add a comment in the order form.


Usual Adult Dose for Postherpetic Neuralgia

Initial dose: 75 mg 2 times a day or 50 mg 3 times a day in patients with a creatinine clearance of at least 60 mL/min

The dose may be increased to 100 mg 3 times a day within 1 week based on efficacy and tolerability.

Maximum dose: Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and who are able to tolerate pregabalin, may be treated with up to 300 mg 2 times a day or 200 mg 3 times a day. Due to the dose-dependent adverse effects and the higher rate of treatment discontinuation due to adverse events, dosing above 300 mg/day should be reserved only for those patients who have ongoing pain and are tolerating 300 mg daily.

Usual Adult Dose for Epilepsy

Initial dose: 75 mg 2 times a day or 50 mg 3 times a day

Doses of 150 mg to 600 mg/day have been shown to be effective as adjunctive therapy in the treatment of partial onset seizures. The total daily dose should be divided and given either 2 or 3 times a day.

Maximum dose: Based on individual patient response and tolerability, the dose may be increased to a maximum of 600 mg/day.

The efficacy of add-on pregabalin in patients taking gabapentin has not been evaluated in controlled trials. Therefore, dosing recommendations for the use of pregabalin with gabapentin cannot be offered.

Usual Adult Dose for Fibromyalgia

Initial dose: 75 mg two times a day (150 mg/day)

The dose may be increased to 150 mg two times a day (300 mg/day) within one week based on efficacy and tolerability.

Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day).

Recommended dose: 300 to 450 mg/day

Although pregabalin was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended.

Usual Adult Dose for Neuropathic Pain

For neuropathic pain associated with spinal cord injury:

Initial dose: 75 mg 2 times a day

The dose may be increased to 150 mg 2 times a day within 1 week based on efficacy and tolerability.

Doses of 150 mg to 600 mg/day have been shown to be effective as adjunctive therapy in the treatment of neuropathic pain associated with spinal cord injury. The total daily dose should be divided.

Maximum dose: Patients who do not experience sufficient pain relief following 2 to 3 weeks of treatment with 150 mg 2 times a day and who are able to tolerate pregabalin, may be treated with up to 300 mg 2 times a day. Because pregabalin is eliminated primarily by renal excretion, the dose should be adjusted in patients with reduced renal function.

Precautions

If pregabalin is to be discontinued, it should be withdrawn gradually over a minimum of one week.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

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Pregabalin-Richter (Lyrica generic)

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